About us

Our C. difficile Structural Microbiology group focuses on detailed structural and functional characterisation of proteins involved in key pathogenicity pathways in this major human pathogen. We are particularly interested in Clostridioides difficile spores, the dormant, resistant cell forms that are the transmission vehicle, as well as surface proteins and their role in infection.

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Our publications

Cleavage of an engulfment peptidoglycan hydrolase by a sporulation signature protease in Clostridioides difficile

Molecular Microbiology, 2024

Cleavage of an engulfment peptidoglycan hydrolase by a sporulation signature protease in Clostridioides difficile

Abstract In the model organism Bacillus subtilis, a signaling protease produced in the forespore, …

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An intact S-layer is advantageous to Clostridioides difficile within the host

PLoS Pathogens, 2023

An intact S-layer is advantageous to Clostridioides difficile within the host

Abstract Clostridioides difficile is responsible for substantial morbidity and mortality in …

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Structure and assembly of the S-layer in C. difficile

Nature Communications, 2022

Structure and assembly of the S-layer in C. difficile

Abstract Many bacteria and archaea possess a two-dimensional protein array, or S-layer, that covers …

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Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment

Molecular Microbiology, 2018

Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment

Abstract Clostridium difficile remains the leading cause of antibiotic-associated diarrhoea in …

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The SpollQ-SpolllAH complex of Clostridium difficile controls forespore engulfment and late stages of gene expression and spore morphogenesis

Molecular Microbiology, 2016

The SpollQ-SpolllAH complex of Clostridium difficile controls forespore engulfment and late stages of gene expression and spore morphogenesis

Abstract Engulfment of the forespore by the mother cell is a universal feature of endosporulation. …

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The engulfasome in C. difficile: Variations on protein machineries

Anaerobe, 2019

The engulfasome in C. difficile: Variations on protein machineries

Abstract Clostridioides difficile infection (CDI) continues to be a substantial healthcare burden, …

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